
Study Suggests It's Wise to Consume Adequate
Copper During PregnancyBy Judy
McBride March 19, 1999Getting enough copper during pregnancy may be important for the baby's brain
development, according to an Agricultural
Research Service study of newborn rat pups. Slashing the mother rats' copper intake during pregnancy and nursing reduced
the pups' brain levels of the enzyme PKC, important to development of the
nervous system. The findings may have implications for people in the U.S. and
other industrialized nations where copper intake is less than desirable.
Between 1.5 and 3 milligrams of copper daily is currently suggested for all
adults. W. Thomas Johnson led the study at ARS' Grand Forks, N. Dak.,
Human Nutrition Research Center.
The brain has several enzymes that would suffer from a shortage of copper.
Some need the mineral to function. Others, like PKC, don't contain copper but
are less active in the absence of the mineral. Johnson and colleagues focused
on PKC, measuring levels in the rat pups' brains after birth. Throughout pregnancy and afterward, one group of mothers got only 1
microgram (mcg) of copper daily--one-sixth the level recommended for pregnant
rats. The second group got 2 mcg, and a control group got all they needed. PKC increased in all the pups' brains during the three weeks after birth.
But compared to the control group, the increase was only about half as much in
the group whose mothers got 1 mcg of copper. Pups from the 2-mcg group also had a smaller increase--25 percent less
overall, with one form of PKC lagging by 50 percent in the cerebellum, which
controls motor function. This is significant, Johnson contends, because poor
muscle coordination is a well-known symptom of copper deficiency in baby
animals. A story about the research appears in the March issue of ARS' Agricultural Research magazine.
The story is also on the World Wide Web at: http://www.ars.usda.gov/is/AR/archive/mar99/moms0399.htm ARS is the U.S. Department of
Agriculture's chief scientific agency. Scientific contact: W. Thomas
Johnson, ARS Grand Forks Human Nutrition Research Center, Grand Forks,
N.D., phone (701) 795-8411, fax (701) 795-8395,
[email protected].
U.S. Department of Agriculture | |