March 2005

UCLA scientists store materials in cells' natural vaults

Method may offer safer way to target drugs to living cells

BACKGROUND: In the realm of nanotechnology, or study of the tiny, scientists often aim to safely deliver and leave material in the human body without causing harm. A big challenge is how to design a package for this biomaterial that will be compatible with living cells and will not provoke an immune reaction. Previous efforts have relied upon viruses or artificial chemicals to house and deliver drugs or other substances to targeted cells.

RESEARCH: Scientists at the David Geffen School of Medicine at UCLA have exploited thousands of tiny capsules in cells to store vast amounts of biomaterial. Dubbed vaults � for their high arches reminiscent of cathedral ceilings � these naturally occurring capsules may prove less likely to elicit an immune response than foreign carriers like viruses.

IMPACT: The UCLA discovery will enable many potential applications, including:

AUTHORS: Leonard Rome, professor of biological chemistry and senior associate dean of research; Bruce Dunn, professor of material science and engineering; Jeffrey Zink, professor of chemistry and biochemistry and Valerie Kickhoefer, first author and associate research biochemist.

JOURNAL: The Proceedings of the National Academy of Sciences
http://www.pnas.org/cgi/content/abstract/0500929102v1

FUNDING: The National Science Foundation supported the research.

(NOTE: Full manuscript and color images of vaults available upon request.)