
May 2003 From Journal of Clinical Investigation JCI Table of Contents, May 1, 2003 Stem cell transplantation prevents autoimmune diabetesBone marrow or hematopoietic stem cell (HSC) transplantation have recently been used to treat clinically severe autoimmune disease, however they are associated with a high risk of graft rejection or graft-versus-host disease. In contrast, Leonard Harrison and colleagues at the Walter and Eliza Hall Institute of Medical Research, Australia demonstrate that syngeneic transplantation of HSCs does not provoke a host immune response and is capable of preventing autoimmune diabetes in mice. AUTHOR CONTACT: Leonard C. Harrison The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. Phone: 61-3-9345-2460 Fax: 61-3-9347-0852 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/15995.pdf
Rare reversion of mutation provides a basis for natural gene therapy A rare inherited disorder known as Wiskott-Aldrich syndrome (WAS) results from a mutation in the WAS protein. Two brothers have been identified that carry a second mutation in this protein, which restored protein function in a fraction of their T cells. Understanding the mechanisms underlying this natural form of gene therapy will be of great importance for developing new therapeutic strategies for genetic disorders. AUTHOR CONTACT: Fabio Candotti NIH, Bethesda, Maryland, USA. Phone: 301-435-2944 Fax: 301-480-3678 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/15485.pdf
Disabling a constitutive CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide AUTHOR CONTACT: Leonard C. Harrison The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. Phone: 61-3-9345-2460 Fax: 61-3-9347-0852 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/17166.pdf ACCOMPANYING COMMENTARY: Peptide-based treatment for autoimmune diseases: learning how to handle a double-edged sword CONTACT: Alberto Pugliese Diabetes Research Institution, University of Miami, Miami, Florida, USA Phone : 305-243-5348 Fax : 305-243-4404 E-mail: [email protected] View the PDF of this commentary at: https://www.the-jci.org/press/18395.pdf
Activation of the m opioid receptor provides calm for the colon Excessive inflammation in the intestine is characteristic of inflammatory bowel disease (IBD). Researchers now show that administration beneath the skin of compounds that selectively inhibit the m opioid receptor in the colon are capable of preventing colitis in mice. These results suggest that such compounds may have therapeutic potential in IBD patients. CONTACT: Pierre Desreumaux, Hopital Huriez, Service de Gastro-enterologie, Lille, France. Phone: 33-3-2044-4714 Fax: 33-3-2044-4713 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/16750.pdf
Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension AUTHOR CONTACT: Lutz-Henning Block University of Vienna, Vienna, Austria. Phone: 43-1-40400-4774 Fax: 43-1-40400-4784 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/17500.pdf
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors AUTHOR CONTACT: Gabriele Bergers UCSF, San Francisco, California, USA. Phone : 415-476-6786 Fax : 415-476-0388 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/17929.pdf ACCOMPANYING COMMENTARY: Double target for tumor mass destruction AUTHORS CONTACT: Kari Alitalo University Of Helsinki, Helsinki, Finland. Phone: 358-9-191 25511 Fax: 358-9-191 25510 E-mail: [email protected] View the PDF of this commentary at: https://www.the-jci.org/press/18539.pdf
Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice AUTHOR CONTACT: Shizuo Akira Osaka University, Osaka, Japan. Phone: 81-6-6879-8302 Fax: 81-6-6879-8305 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/17085.pdf ACCOMPANYING COMMENTARY: Connecting the dots from Toll-like receptors to innate immune cells and inflammatory bowel disease AUTHOR CONTACT: Averil Ma University Of Chicago, Chicago, Illinois, USA. Phone: 312-702-4708 Fax: 312-702-2281 E-mail: [email protected] View the PDF of this commentary at: https://www.the-jci.org/press/18545.pdf
PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance AUTHOR CONTACT: Alan R. Saltiel The University of Michigan Medical Center, Ann Arbor, Michigan, USA. Phone : 734-615-9787 Fax : 734-936-2888 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/17975.pdf ACCOMPANYING COMMENTARY: Tissue glycogen content and glucose intolerance AUTHOR CONTACT: Masato Kasuga Kobe University School of Medicine, Kobe, Japan. Phone: 81-78-382-5860 Fax: 81-78-382-2084 E-mail: [email protected] View the PDF of this commentary at: https://www.the-jci.org/press/18526.pdf
Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A AUTHOR CONTACT: Michaela Kuhn University of Muenster, Muenster, Germany. Phone : 49-251-83-52597 Fax : 49-251-83-55501 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/17061.pdf ACCOMPANYING COMMENTARY: A friend within the heart: natriuretic peptide receptor signaling AUTHOR CONTACT: Jeffrey Molkentin Children's Hospital Medical Center, Cincinnati, Ohio, USA. Phone : 513-636-3557 Fax : 513-636-5958 E-mail: [email protected] View the PDF of this commentary at: https://www.the-jci.org/press/18389.pdf
A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor�deficient mice AUTHOR CONTACT: Roland Baron Yale University School of Medicine, New Haven, Connecticut, USA. Phone: 203-785-4150 Fax: 203-785-2744 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/17246.pdf
Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer AUTHOR CONTACT: Roland W. Herzog The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. Phone: 215-590-4907 Fax: 215-590-3660 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/16887.pdf
The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance AUTHOR CONTACT: Ronald Khan Joslin Diabetes Center, Boston, Massachusetts, USA. Phone: 617-732-2635 Fax: 617-732-2593 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/15211.pdf
The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men AUTHOR CONTACT: Christos S. Mantzoros Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. Phone: 617-667-2151 Fax: 617-667-2927 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/17490.pdf Wire services: All wire service stories must carry the embargo time at the head of each item and may not be sent out more than 24 hours before that time. Warning: This document and the Journal of Clinical Investigation papers to which it refers, may contain information that is price sensitive with respect to publicly quoted companies. Anyone dealing in securities using information contained within this document or within advance copies of the JCI, may be guilty of insider trading under the US Securities Exchange Act of 1934. |