
May 2003 From Journal of Clinical Investigation JCI table of contents, May 15, 2003Arrhythmia unraveled Approximately half of all individuals implanted with pacemakers suffer from sinus node dysfunction. A new study of one such patient reveals a previously unknown mutation in the gene thought to primarily regulate the rhythmicity of the beating heart. TITLE: Pacemaker channel dysfunction in a patient with sinus node disease CONTACT: Schulze-Bahr, Eric Department of Cardiology, Hospital of the University of M�nster, M�nster, Germany. Phone: 49-251-835-2982 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/16750.pdf
Throwing lupus for a loop Lupus, an autoimmune disease primarily affecting women of childbearing age, is treated with steroids that often leave patients susceptible to infections, diabetes, and high blood pressure. A new study in non-human primates reports that treatment with specific antibodies can reverse established disease without the side effects associated with current steroid-based therapies. TITLE: CD137 costimulatory T cell receptor engagement reverses acute disease in NZB x NZW F1 lupus-prone mice AUTHOR CONTACT: Robert Mittler Emory University School of Medicine, Atlanta, Georgia, USA. Phone: 404-727-9425 Fax: 404-727-8199 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/17662.pdf
Programmed death of cardiac cells can cause heart failure TITLE: A mechanistic role for cardiac myocyte apoptosis in heart failure AUTHOR CONTACT: Richard Kitsis Albert Einstein College Of Medicine, Bronx, New York, USA. Phone 1: 718-430-2609 Phone 2: 718-430-2000 Fax: 718-430-8991 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/17664.pdf RELATED ARTICLE: TITLE: Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy AUTHOR CONTACT: Junichi Sadoshima New Jersey Medical School and Hackensack University Medical Center, Newark, New Jersey, USA. Phone: 973-972-8916 Fax: 973-972-8919 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/17459.pdf ACCOMPANYING COMMENTARY: A matter of life and death: cardiac myocyte apoptosis and regeneration AUTHOR CONTACT: Bernado Nadal-Ginard New York Medical College, Valhalla, New York, USA. Phone: 617-510-5769 E-mail: [email protected]. View the PDF of this commentary at: https://www.the-jci.org/press/18611.pdf
Host proteins prove to be antibactericidal all on their own TITLE: Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability. AUTHOR CONTACT: Francis X. McCormack University of Cincinnati School of Medicine, Cincinnati, Ohio, USA. Phone: 513-558-0480 Fax: 513-558-0835 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/16889.pdf ACCOMPANYING COMMENTARY: Pulmonary surfactant: a front line of lung host defense AUTHOR CONTACT: Jo Rae Wright Duke University School Of Medicine, Durham, North Carolina, USA. Phone: 919-684-8040 Fax: 919-684-8106 E-mail: [email protected] View the PDF of this commentary at: https://www.the-jci.org/press/18650.pdf
CD44's role in allergic airway inflammation and asthma TITLE: A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia AUTHOR CONTACT: Shigeki Katoh Miyazaki Medical College, Kiyotake, Myazaki, Japan Phone: 81-985-85-2965 Fax: 81-985-85-8305 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/16583.pdf ACCOMPANYING COMMENTARY: CD44 -- a sticky target for asthma AUTHOR CONTACT: Marc E. Rothenberg Children's Hospital Medical Center, Cincinnati, Ohio, USA. Phone: 513-636-7210 Fax: 513-636-3310 E-mail: [email protected] View the PDF of this commentary at: https://www.the-jci.org/press/18392.pdf
New path to therapy for pulmonary hypertension Current treatments for pulmonary hypertension are only capable of delaying progression of the disease and lung transplantation is ultimately necessary. Researchers have now found that mice deficient of a factor known as HIF-2a are protected against pulmonary hypertension, indicating that pharmaceutical inhibitors of this factor may be useful in the prevention or reduction of pulmonary hypertension. TITLE: Heterozygous deficiency of hypoxia-inducible factor-2a protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia AUTHOR CONTACT: Peter Carmeliet KU Leuven, Flanders Interuniversity Institute of Biotechnology, Leuven, Belgium. Phone 1: 32-16-345-772 Phone 2: 32-16-345-780 Fax: 32-16-345-990 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/15496.pdf
At the heart of hypertrophy TITLE: Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling AUTHOR CONTACT: Jeffrey D. Molkentin Children's Hospital Medical Center, Cincinnati, Ohio, USA. Phone: 513-636-3557 Fax: 513-636-5958 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/17295.pdf
Alternative strategy for tumor immunotherapy TITLE: Antigenic drift as a mechanism for tumor evasion of destruction by cytolytic T lymphocytes AUTHOR CONTACT: Yang Liu Ohio State University Medical Center, Columbus, Ohio, USA. Phone: 614-292-3054 Fax: 614-688-8152 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/17656.pdf
Cardiac muscle gets excited TITLE: Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppression AUTHOR CONTACT: Bradley Nuss University of Maryland School of Medicine, Baltimore, Maryland, USA. Phone: 410-706-1134 Fax: 410-706-8610 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/17959.pdf
Distinguishing self from non-self in transplant rejection TITLE: Critical role of Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection AUTHOR CONTACT: Daniel Goldstein Yale University, New Haven, Connecticut, USA. Phone: 203-785-3271 Fax: 203-737-1801 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/17573.pdf
The cardiovascular effects of cholesterol carriers and estrogen TITLE: HDL-associated estradiol stimulates endothelial NO synthase and vasodilation in an SR-BI�dependent manner AUTHOR CONTACT: Eric Smart University of Kentucky, Lexington, Kentucky, USA. Phone: 859-323-6412 Fax: 859-323-1070 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/16777.pdf
Glucose sensing and signaling TITLE: GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor�stimulated muscle glucose utilization AUTHOR CONTACT: Bernard Thorens University Of Lausanne, Lausanne, Switzerland. Phone: 41-21-692-53-90 Fax: 41-21-692-5355 E-mail: [email protected] View the PDF of this article at: https://www.the-jci.org/press/16888.pdf
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