February 2001

From Cold Spring Harbor Laboratory

Fathers of Finland

The origins of the Saami, a nomadic culture in the north of Scandinavia and Finland, have long been debated. Both the Saami and the Finns are distinct from most Europeans in speaking Uralic, rather than Indo-European, languages. Geneticists trying to decipher anthropologically murky origins have been limited by cumbersome methods for genetic sampling, but this month Ann-Christine Syv�nen and colleagues from the National Public Health Institute in Finland report an efficient method for 'gene-typing' individuals using the latest information from the human genome project. Using these methods, the researchers find evidence that two settlement waves originated the present population of Finland.

Scientists have found that the human Y chromosome contains a number of gene variations, called SNPs, which can be used to trace paternal lineage in human populations. In the current study, Syv�nen and colleagues report a method using 'gene chips' to simultaneously detect dozens of SNPs in an individual. The researchers used this method to analyze 25 Y chromosome SNPs in men from three different regions of Finland, three groups of Saami, and two other populations belonging to the Uralic language group. Out of six specific SNP combinations found in these populations, two combinations prevail among both the Finns and the Saami. Moreover, the relative prevalence of these two SNP profiles appears to vary between the Western and the Northern/Eastern Finns and subgroups of the Saami. These results support the idea that two separate groups settled Finland and point to shared genetic structure between the Finns and the Saami.

Contact (author):
Ann-Christine Syv�nen
Department of Human Molecular Genetics
National Public Health Institute Helsinki
Finland
Email: [email protected]



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