LOS ANGELES, Jan. 6, 1997 -- Geneticists working on the Human Genome Project have sequenced just 2 percent of the 3 billion DNA base pairs that make up our genetic code. Yet, many are already looking ahead to what's next, namely, what scientists will do once they've mapped out all of the human genes.

On Jan. 23, 1998, USC and visiting scholars will convene at the second annual Institute for Genetic Medicine Symposium, "Genomic Genetics," to explore what forms post-Genome Project research may take.

Nobel Prize-winning biologist David Baltimore, now president of California Institute of Technology in Pasadena, will begin the day-long conference with a keynote speech entitled "Cell Life and Cell Death." In subsequent presentations, some of the nation's leading geneticists will speak about their gene studies on a wide range of living things -- from bacteria and yeast to plants, mice and humans.

"In the future, human geneticists will think genomically, rather than one gene at a time," said Juergen Reichardt, USC School of Medicine assistant professor of biochemistry and molecular biology and symposium organizer. "Complex human traits are clearly determined by multiple genes and most probably by other factors. In these cases a genomic approach is more appropriate."

Based on what's happened with E. coli and yeast, two of the first goals will be figuring out the function of the genes that have been sequenced and applying that information in the clinic. Scientists may also find it easier to study evolutionary relationships, how genes interact with each other and how genes interact with the environment. What's most exciting to some scientists is that access to the genomic sequence will enable them to spend more time investigating -- hunting for links between genes and disease, for example -- instead of doing rote gene cloning.

Symposium speakers will include:

• David Bramhill, a biochemist at Merck Research Laboratories in Rahway, NJ, who will speak about how having the complete E. coli genome in hand has led to innovation in drug development.
• Yale University biologist Michael Snyder will discuss his research on the yeast genome, which is the first fully-sequenced genome of an organism with nucleated, or eukaryotic, cells like our own. Snyder is studying how to best tease out the functions of the yeast's thousands of genes.
• Elliot Meyerowitz, a biologist at Caltech who studies Arabidopsis plants, the "fruit fly" of plant genetics, will discuss his findings that all multicellular organisms, animal or vegetable, share common developmental pathways, long conserved in the genetic code.
• Geneticist Nancy Jenkins, who heads up the molecular genetics of development section at the National Cancer Institute's Frederick Cancer Center in Maryland, will discuss her work on gene expression in mice.
• University of Iowa researcher Val Sheffield will speak about hunting for disease genes in the human genome.
• Huntington Willard of Case Western Reserve University in Cleveland, will speak about artificial human chromosomes, which researchers may one day use for gene therapy.

The free symposium is sponsored, in part, by the Lucille P. Markey Charitable Trust. It will begin at 9 a.m. in the Mayer Auditorium at the USC Health Sciences Campus. The event is open to the media and to the public on a first-come, first-serve basis.

Immediately following, the IGM will host an open house in its newly renovated, gene-themed space in the IGM Building on USC's Health Sciences Campus at 2250 Alcazar St., where visitors may eat, drink and think genomic. Interviews can be arranged. Please find a full schedule of speakers and times enclosed