1998
From: American Urological Association
In Vitro Functional Properties Of The Rat Bladder Regenerated By The Bladder Acellular Matrix Graft Cystectomy, or surgical removal of the bladder, is performed as a procedure to try to stop widespread cancer in that organ. After the surgery, urine is often passed through a specially constructed channel emerging in a mouth-like opening in the lower abdomen. It represents major surgery, requiring life-style changes for the patient. In a series of trials with Sprague Dawley rats, these investigators tested the response of the rat urinary bladder to a new type of graft reconstruction material. After removing more than 50% of the rat bladders, they performed reconstruction procedures with bladder acellular matrix graft (BAMG). About 4 months after surgery, in vitro studies of tissue strips showed that the maximum forces of contraction in the BAMG regenerates, responding to a chemical designed to stimulate urinary bladder smooth muscle contraction, hit 80% of the host bladder response. Histologic and immunohistochemical studies confirmed the presence of receptors for neurotransmitters on the BAMG regenerat es that the functional in vitro studies implied. The researchers believe that this study provides evidence that reconstruction with BAMG leads to functional regeneration of the rat bladder.
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