1998
From: American Urological Association
Age, PSA And The Chance Of Curable Prostate Cancer Among Men With Non-Palpable Disease The objective of this research was to evaluate whether older men had more extensive prostate cancer than younger males at the same PSA level. A series of 492 men who had radical prostatectomies was divided into three age categories: 69 men into the 40 - 50-year-old bracket; 227 men into the 51 - 60 age group; and 196 men into the 61 to 73-year-old category. Then the groups were further divided into five PSA levels: 2.5 - 4.0 ng/ml; 4.1 - 6.0 ng/ml; 6.1 - 8.0 ng/ml; 8.1 - 10.0 ng/ml; and over 10 ng/ml. The researchers defined curable prostate cancer as either an organ-confined tumor, or a low grade penetration with negative margins and no involvement of seminal vesicles or lymph nodes. After running an analysis of their data, they concluded that, at the same PSA level, older men are more likely to have extensive prostate cancer than younger men. Furthermore, they do not advocate setting higher PSA thresholds for older men because such a change might compromise the cure rate.
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