Sunlight and serotonin underlie seasonal mood disorders

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The success of phototherapy (ultraviolet light therapy to stimulate brain neurotransmitter activity) and drugs that prevent the reuptake of the neurotransmitter serotonin have suggested that serotonin itself has a role in the development of seasonal depression. However, concentrations of serotonin and other neurotransmitters including dopamine and norepinephrine are normal in the cerebrospinal fluid of patients with seasonal affective disorder.

Gavin Lambert from the Baker Research Institute, Melbourne, Australia, and colleagues investigated whether measurement of serotonin concentrations from blood vessels draining the brain--a more accurate way of measuring serotonin concentrations in the brain than by analysis of cerebrospinal fluid--might provide stronger evidence for the role of serotonin in mood disorders. The investigators took blood samples from internal jugular veins in 101 healthy men to assess the relation between serotonin concentration and weather conditions and season.

The turnover of serotonin by the brain was lowest in winter, and the rate of production of serotonin by the brain was directly related to the prevailing duration of bright sunlight.

Gavin Lambert comments: "Our observations suggest that the prevailing amount of sunlight affects brain serotonergic activity, and thus underlies mood seasonality and seasonal affective disorder, although we do not know whether patients predisposed to affective disorders are affected by environmental factors in the same way as our healthy volunteers."

Contact: Kristen Boschma, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne Vic 8008, Australia; T) +61 3 8532 1140; F) +61 3 8532 1100; E) [email protected]